![]() ![]() ![]() The extemporaneous preparation was not susceptible to microbial contamination. The visual appearance, odour, pH and specific gravity remained fairly unchanged throughout the study period and the content of Phenobarbitone remained above 98% of the original concentration throughout the course of the study for both temperatures. The content of Phenobarbitone was determined using a validated high-performance liquid chromatography (HPLC) method. The Phenobarbitone Oral Suspension (10mg/ml) was stored at 4oC and 30oC / 75%RH protected from light and were examined at the interval of 0, 1, 2, 3 and 6 months. The objective of this study is to evaluate the physicochemical and microbiological stability of an extemporaneously prepared Phenobarbitone Oral Suspension using commercially available tablets and X-temp Oral Suspension System. Phenobarbitone is the main anti-epileptic drug (AED) for the treatment of seizure in paediatric patients. Many drugs used in paediatric are often not available in suitable dosage forms and have to be extemporaneously prepared by pharmacists to make them suitable for the body weight, body surface area, or age of the children.
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